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Browsing by Author "Al-Fareed, Tahani Mohammed Ahmad"

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    Synthesis of Novel Magnetoelectric Nanocomposites as Advanced anti-cancer drug in vitro
    (2021) Al-Fareed, Tahani Mohammed Ahmad; منيرة بنت عبدالله المصيرعي
    Magnetoelectric nanocomposites are a new generation of multiferroics materials that have great potential in enormous fields owing to their unique properties. The conjunction between ferroelectric and ferromagnetic phases provides a direct and indirect exchange between magnetic, and electric properties. The core-shell diphasic systems are the most attractive structure for different applications due to presence of strong magnetoelectric coupling at room temperature. In the present thesis, we have synthesized several spinel ferrites’ groups MFe1.8O4 , Co0.5A0.5Fe1.8O4, Co0.8Mn0.2R0.02Fe1.8O4 , Ni0.5Zn0.5R0.02Fe1.8O4 , Zn1-2xCaxMgxFe1.8O4 (M= Co, Ni , Zn , Cu, Mg , or Mn ; A=Ni, Cu, Mg, Zn, or Mn ; R = Ce , Eu , Tb ,Tm, or Gd ; x = 0.05 , 0.1 , 0.15 , 0.2 , 0.25 , 0.3) as a magnetic core part by sonochemical method. Then, each spinel ferrite nanoparticles SFNPs was coated with barium titanate BaTiO3 (noted as BTO) by sol-gel method to form various core-shell of MFe1.8O4@BTO , Co0.5A0.5Fe1.8O4@BTO, Co0.8Mn0.2R0.02Fe1.8O4@BTO , Ni0.5Zn0.5R0.02Fe1.8O4@BTO , Zn1-2xCaxMgxFe1.8O4@BTO (M= Co, Ni , Zn , Cu, Mg , or Mn ; A=Ni, Cu, Mg, Zn, or Mn ; R = Ce , Eu , Tb ,Tm, or Gd ; x = 0.05 , 0.1 , 0.15 , 0.2 , 0.25 , 0.3) magnetoelectric nanocomposites (MENs). The microstructure and morphology of core-shell MENs were evaluated through XRD, SEM, TEM and EDS as well as the magnetoelectric measurements. The different characterization techniques confirmed the purity and the successful formation of core-shell MENs. The average crystallite size was calculated via Sherrer’s equation and are estimated to be in the range of 24 to 29 nm. The biological impact of SFNPs and core-shell MENs were examined by MTT assay and nuclear DAPI staining on (human colorectal carcinoma cells) HCT-116 and (human embryonic kidney cells) HEK-293. We have found that the magnetic core treatment exhibited a significant reduction in cancer cell viability as well as they induced nuclear condensation, cell membrane disintegration, and cell death as revealed by DAPI staining. However, there was a negligible or no toxicity for core-shell MENs treatment at 141.75 µg/0.1ml, suggesting that the BTO coating improve the biocompatibility of SFNPs. Hence, the MENs seem to be ideal as they are non-toxic, and they can be a promise candidate for anticancer drug delivery and magnetoelectric voltage generator.