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عمادة السنة التحضيرية|Deanship of Preparatory Year & Supporting Studies

Permanent URI for this collectionhttps://repository.iau.edu.sa/handle/123456789/486

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    Synergistic action of curcumin and cisplatin on spinel ferrite/hierarchical MCM-41 nanocomposite against MCF-7, HeLa and HCT 116 cancer cell line
    (2021) Nora Khalid AlSudairi; Atheel Awad Almofleh; Tahani M. Alfareed; Vijaya Ravinayagam; Rubavathi Marimuthu
    Background: Platinum-based drugs are widely used in cancer therapy, but are known for toxic side effects and resistance. Combinational drug delivery represents an effective chemotherapeutic strategy, but often leads to an increased toxicity. Aim of this study is to test the co-delivery of cisplatin with natural antioxidants on hierarchial porous large surface area hexagonal nanocarriers for synergistic action. Results: A series of structured mesoporous materials were impregnated with magnetic spinel ferrite (30% CuFe2O4) and then coated with curcumin (25% wt/wt). Mesosilicalite and MCM-41 with high curcumin release abilities were functionalized with cisplatin (5% wt/wt) for synergistic effect of combinational drugs. The cytotoxic efficiency of our nanocomposites was tested on cell viability of MCF7 (human breast cancer), human cervical cancer (HeLa), colorectal cancer (HCT116), and HFF (human foreskin fibroblasts) cell lines using the MTT cell viability assay. At a concentration of 0.1 mg/ml, CuFe2O4/mesosilicalite/curcumin/cisplatin resulted in 89.53% reduction in viability in MCF7, 94.03% in HeLa, 64% in HCT116 and 87% in HFF; whereas, CuFe2O4/MCM-41/curcumin/cisplatin resulted in 76% reduction in viability in MCF7, 64.46% in HeLa, 64% in HCT116 and 24% in HFF. The EC50 for CuFe2O4/mesosilicalite/curcumin/cisplatin was 81.23 mu g/ml in MCF7, 47.55 pg/ml in HeLa, 48.96 mu g/ml in HCT116 and 76.83 mu g/ml in HFF. The EC50 for CuFe2O4/MCM-41/curcumin/cisplatin was 72.51 mu g/ml in MCF7, 58.6 mu g/ml in HeLa, 62.58 mu g/ml in HCT116 and 154.2 mu g/ml in HFF. Furthermore, cells treated with both nanocomposites had a high number of cleaved Caspase 3-positive cells suggesting that the reduction in cell viability was triggered by activating the apoptotic signaling pathway. Conclusion: Our results show that CuFe2O4/MCM-41/curcumin/cisplatin is a better candidate for combinational drug therapy due to its lowest EC50 value and the wider difference in EC50 (a fold change) between cancerous and non-cancerous cell line.
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    Preparation and In Vitro-In Vivo Evaluation of Luteolin Loaded Gastroretentive Microsponge for the Eradication of Helicobacter pylori Infections
    (2021) M. S. Jafar, MohammedKhan, Mohd Sajjad AhmadAlshehry, YasirAlrwaili, Nazar RadwanAlzahrani, Yazeed AliImam, Syed SarimAlshehri, Sultan
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    Physicochemical Properties of Nanofluids Produced from Oxidized Nanoparticles Synthesized in a Liquid by Pulsed Laser Ablation
    (2022) Tahani Flemban; Ridha Hamdi; Hassan Alkhabbaz; Khaled Elsayed; Muidh Alheshibri
    Since pulsed laser ablation in liquid is the most common, simple, and efficient technique to synthesize nanoparticles (NPs). In this work, pure aluminum (Al) and pure copper (Cu) targets are located inside a liquid ambient, next a Nd-YAG Laser of 1064 nm wavelength and 10 Hz pulse repetition is used at four different pulse energies of 30, 50, 70, and 90 mJ to produce Al-NPs and Cu-NPs. After that, a comparative/superlative study, and the physicochemical properties of the prepared nanofluids, (Al-NFs) and (Cu-NFs), have been carried out using transmission electron microscope, scanning electron microscopy with energy-dispersive X-ray spectroscopy, zeta-sizer, UV-Vis spectroscopy, density meter, and viscometer. The influence of laser energy on these properties have been investigated as well.
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    Tuning the Structure, Magnetic, and High Frequency Properties of Sc-Doped Sr0.5Ba0.5ScxFe12-xO19/NiFe2O4 Hard/Soft Nanocomposites
    (2022) Almessiere, M. A. Slimani, Y. Algarou, N. A. Vakhitov, M. G. Klygach, D. S. Baykal, A. Zubar, T. I. Trukhanov, S. V. Trukhanov, A. V. Attia, H. Sertkol, M. Auwal, I. A.; Norah A. Algarou; M. Sertkol
    The Sr0.5Ba0.5ScxFe12-xO19(SrBaSc)/NiFe2O4(NiFe) hard-soft nanocomposites (NCs) are synthesized by in situ sol-gel route. Impact of Sc3+ doping on their structure, morphology, and magnetic properties are examined. X-ray diffraction confirms the coexistence of SrBaSc and NiFe phases without any impurity. Morphology of NCs reveals a cluster of hexagonal plate decorated by spherical grains. Magnetic characteristics of the NCs are examined by using a vibration sample magnetometer at room temperature and 10 K. The x = 0.000 sample shows some kinks in their M-H loops and the occurrence of two peaks in dM/dH(H). All the NCs with Sc3+ exhibit smooth shapes of M-H curves with single peak, revealing the complete and perfect exchange coupling behavior. The diverse magnetic parameters at both temperatures are determined. The values of saturation and remanent magnetizations are decreasing with the Sc content increase. The intensive electromagnetic absorption is observed in all the samples. Reflection loss (RL) of more than -18 dB is observed above 3 GHz. Strong coupling between Sc concentration and amplitude-frequency characteristics of the RL can be used for developing of the functional media for high-frequency devices and will open broad perspectives for practical application in radar-absorbing technology and electromagnetic compatibility.